It is our great pleasure to welcome you to the 21st Annual Meeting of the Portuguese Society of Human Genetics (SPGH), in Lisbon. We are immensely grateful to all our sponsors for making this meeting possible again, and to all the members of the Local Organizing Committee and the Scientific Committee, whom we wish to address a special acknowledgement. In a moment when Personalized Medicine is an emerging approach for disease diagnosis, treatment and prevention, providing extraordinary opportunities to improve public health, the SPGH Organizing Committee and the Scientific Committee made their best effort to organize an appealing program with lectures delivered by leading national and international scientists, who will present exceptional findings in the Human Genetics of Personalized Medicine field. We are looking forward to listening to our outstanding invited senior lecturers, as well as the young researchers who will present their works that have been selected among the submitted abstracts—a highly stimulating and exciting meeting, we presume. We received a remarkable number of abstract submissions, which demonstrates how important Human Genetics has become, nowadays.